effect of maximal versus supra-maximal exhausting race on lipid peroxidation, antioxidant activity and muscle-damage biomarkers in long-distance and middle-distance runners

conclusions maximal and supra-maximal races induce a significant increase in lipid peroxidation and cause non-negligible inflammation and muscle damage. these effects were relatively related to the physical exercise type and the sportive specialty. results a significant increase in malondialdehyde (mda) concentrations was observed in ss and mdr after the vameval test and in ldr after the limited-time test. a significant difference was also observed between ldr and the other two groups after the vameval test, and between ldr and mdr after the limited-time test. significant modifications, notably, in myoglobin, ck, ldh, il-6, tnf-α, and tas were likewise noted but depending on the race-type and the sportive specialty. materials and methods the study has been carried out on 8 middle-distance runners (mdr), 9 long-distance runners (ldr), and 8 sedentary subjects (ss). each subject has undergone two exhaustive running tests, the first one is an incremental event (vameval test), the second one is a constant supra-maximal intensity test (limited-time test). blood samples were collected at rest and immediately after each test. background exhausting physical exercise increases lipid peroxidation and causes important muscle damages. the human body tries to mitigate these adverse effects by mobilizing its antioxidant defenses. objectives this study aims to investigate the effect of a maximal versus supra-maximal race sustained until exhaustion on lipid peroxidation, antioxidant activity and muscle-damage biomarkers in trained (i.e. long-distance and middle-distance runners) and sedentary subjects.